Benjamin Thomas Goult

Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

The KN domain of KANK proteins contains separable talin-binding and intramolecular interaction modules

This study identifies separable talin-binding and intramolecular interaction modules within the KN domain of KANK proteins, revealing a modular regulatory architecture.

Subcellular pharmacology of a novel cell-permeable fluorescent phosphodiesterase inhibitor using advanced fluorescence microscopy

The paper develops a fluorescent PDE4 inhibitor to visualize drug-target interactions in living cells using advanced fluorescence microscopy techniques.

An internal PDZ-binding motif in Densin-180 promotes activity-dependent SHANK scaffold remodelling

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

Talin controls the spatial distribution of vinculin tension in focal adhesions

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

Filopodome proteomics identifies CCT8 as a MYO10 interactor critical for filopodia functions

The paper identifies CCT8 as a MYO10 interactor critical for filopodia functions through proteomics and functional studies in cancer cells.

Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

A subpopulation of Talin 1 resides in the nucleus and regulates gene expression

This study identifies a nuclear subpopulation of Talin 1 that regulates gene expression in human breast epithelial cells.

Talin1 dysfunction is genetically linked to systemic capillary leak syndrome.

The paper identifies a rare TLN1 splice-site variant in a familial SCLS case, linking Talin1 dysfunction to systemic capillary leak syndrome through disrupted endothelial barrier integrity.

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin

This paper introduces a single-construct optogenetic tool to control talin dimerization, enabling precise manipulation of mechanotransduction in integrin-based adhesions.

The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease.

This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.

Next generation protein-based materials capture and preserve projectiles from supersonic impacts

This paper develops a protein-based material that absorbs supersonic impacts and preserves projectiles, demonstrating its effectiveness in capturing and preserving hypervelocity projectiles.

The MeshCODE to scale - Visualising synaptic binary information.

The paper introduces the MeshCODE model to visualize synaptic binary information through structural analysis of talin and vinculin scaffolding proteins.

ProLIF: a quantitative assay for investigating integrin cytoplasmic protein interactions and synergistic membrane effects on proteoliposomes

ProLIF quantitatively measures integrin-protein interactions in proteoliposomes using flow cytometry, enabling analysis of membrane effects on protein recruitment.