Lymphatic vessel dysfunction contributes to severe dengue pathogenesis
Fatima Abukunna, Daniel Matamala Luengo, Aitana Martin Manrique, Justin Duruanyanwu, Matthew Sherwood, Priyanka Patel, Mark J. Crabtree, Graeme M. Birdsey, Kevin Maringer, Paola Campagnolo
This study shows that DENV-2 NS1 disrupts lymphatic endothelial cell function, causing hyperpermeability and impaired lymphangiogenesis, contributing to severe dengue pathogenesis.
bioRxiv · Mar 27, 2026 · PreprintMicrobiology