Graeme M. Birdsey

This study shows that DENV-2 NS1 disrupts lymphatic endothelial cell function, causing hyperpermeability and impaired lymphangiogenesis, contributing to severe dengue pathogenesis.

This study shows ZONAB regulates endothelial cell senescence by controlling DNA methylation and mitochondrial function, impacting angiogenesis and vascular health.

This study shows that overexpressing ERG in endothelial cells prevents vascular regression and neuronal damage in OIR models, suggesting ERG as a potential therapeutic target for retinopathies.

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

This study uses a computational framework to analyze genetic data from 77,539 genomes, identifying 21 novel genetic associations with 269 rare diseases.