Dissecting the interactions of the ISG15-USP18-STAT2 inhibitory complex
Jessica C Rowe, Yi Min Ng, Hannah Kiefer, Matthew Simmons, Marilyn Paul, Ramasubramanian Sundaramoorthy, David J. Hughes, Kirby N. Swatek
This study investigates the ISG15-USP18-STAT2 inhibitory complex's structure and function using AlphaFold and biochemical methods, revealing critical residues and patient mutations affecting its interaction.
bioRxiv · Mar 27, 2026 · PreprintBiochemistry