BiochemistrybioRxivPreprint
Dissecting the interactions of the ISG15-USP18-STAT2 inhibitory complex
Jessica C Rowe, Yi Min Ng, Hannah Kiefer…·Kirby N. Swatek
This study investigates the ISG15-USP18-STAT2 inhibitory complex's structure and function using AlphaFold and biochemical methods, revealing critical residues and patient mutations affecting its interaction.
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