Marilyn Paul

This study investigates the ISG15-USP18-STAT2 inhibitory complex's structure and function using AlphaFold and biochemical methods, revealing critical residues and patient mutations affecting its interaction.

This study determines the structural morphology and formation of the human exocyst complex, revealing an extended architecture with minimal intersubunit interaction and a single nucleation site.

This study characterizes small molecule inhibitors of the HsRNMT-RAM complex, showing competitive binding and uncompetitive inhibition of RNA cap methylation.

The paper determines the crystal structures of unloaded and cargo-loaded VSR1-Nt, revealing two cargo binding sites and a calcium-dependent mechanism for cargo binding and release.

The paper shows ATP-competitive inhibitors paradoxically activate GCN2 through allosteric activation and autophosphorylation, suggesting alternative strategies for GCN2 inhibition.