H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
Meghana S. Oak, Marco Stock, Matthias Mezes, Tobias Straub, Antony M. Hynes-Allen, Jelle van den Ameele, Ignasi Forné, Andreas W. Ettinger, Axel Imhof, Antonio Scialdone, Eva Hörmanseder
This study shows that H3K4 methylation acts as an epigenetic memory to support zygotic genome activation and embryonic development in Xenopus laevis.
bioRxiv · Jan 20, 2025 · PreprintDevelopmental Biology