Ignasi Forné

The paper establishes hybrid Drosophila cell lines to study genome instabilities and identifies incompatibility genes and chromosomal regions prone to loss in hybrids.

This study identifies reversible and persistent molecular changes in diet-induced obesity using multi-omic analysis, showing that microbial functional profiles drive persistent alterations.

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

The paper identifies two methyltransferases, PCKMT and AKMT, that regulate motility initiation in apicomplexan parasites through coordinated actin nucleation and force propagation.

The paper uses mass spectrometry to analyze histone modifications during mitotic entry, identifying three phosphorylation programs and showing H3 T3 phosphorylation marks heterochromatin, not just centromeres.

This study uses mass spectrometry imaging and laser capture microdissection to analyze histone proteoforms in RTT mouse models, revealing neuron-specific differences and mutation-dependent chromatin changes.

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

The paper identifies hangover's role in regulating gene expression by inhibiting NSL-mediated H4K16 acetylation at transcriptional start sites in Drosophila.

The paper shows SCAMP3 is essential for neutrophil granule formation and function, with Scamp3-deficient neutrophils showing impaired bacterial killing in vitro.

The paper identifies a molecular switch at the yeast mitoribosomal tunnel exit that regulates cytochrome b synthesis by mediating interactions between translational activators and assembly factors.

This study identifies H3K27ac as an epigenetic barrier to reprogramming-induced cell fate changes using an AI-based approach and shows that reducing H3K27ac improves reprogramming efficiency.

This study shows that H3K4 methylation acts as an epigenetic memory to support zygotic genome activation and embryonic development in Xenopus laevis.

This study shows that Chameau (HBO1) enhances starvation resilience in Drosophila melanogaster at lower temperatures, but its role diminishes at higher temperatures.

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

The paper investigates how cellular and epigenetic contexts influence Neurog2 binding and its functional consequences in mouse embryonic stem cells and neural progenitor cells, revealing cell-type-specific chromatin accessibility and interactors.

This study identifies SAMD1 as a repressor of EMT-related genes in PDAC, showing that its loss increases migration and that FBXO11 ubiquitinates SAMD1 to inhibit its function.

This study shows IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent excessive inflammation in AML cells, revealing a potential therapeutic target.

This study shows that Bru1 regulates cytoskeleton dynamics and a splicing transition during Drosophila flight muscle development, leading to structural defects when disrupted.

The paper shows that inhibiting cell proliferation during Xenopus embryogenesis leads to abnormal histone modification profiles, suggesting that cell division influences chromatin maturation and developmental decisions.

This study identifies Morc3 as a key regulator of ERV silencing by enabling Daxx-mediated H3.3 incorporation, revealing a mechanism for chromatin modification and repression.

The paper models the propagation and stability of K27 and K36 methylation landscapes using computational methods and mass spectrometry data.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.