Jelle van den Ameele

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

mRNA-LNP therapy restores systemic nucleoside imbalance in a mitochon-drial DNA depletion syndrome

This study develops mRNA-LNP therapy for MNGIE, restoring nucleoside balance and TP expression in mice through subcutaneous delivery.

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo

The paper uses single-molecule FISH to study mtDNA heteroplasmy dynamics in Drosophila and human cells, revealing developmental bottlenecks and selection effects on mutation load.

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy

Hypoxia promotes airway differentiation in the human lung epithelium

This study shows hypoxia promotes airway differentiation in human lung epithelial progenitors through HIF pathways, with implications for lung disease.

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants

The paper identifies a silencer element lost in ADLD patients that specifically targets oligodendrocyte overexpression of LMNB1, linking it to disease pathogenesis.

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development

This study shows that H3K4 methylation acts as an epigenetic memory to support zygotic genome activation and embryonic development in Xenopus laevis.

Targeted DamID detects cell-type specific histone modifications in vivo

The paper introduces Targeted DamID to detect cell-type specific histone modifications in vivo across different model organisms.

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

The paper uses a CRISPRi screen in human fetal lung organoids to identify SOX9 as a key regulator of progenitor self-renewal, showing it primes cells to receive WNT and RTK signals.

Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamID

This study identifies novel CHD8 genomic targets in fetal mouse brain using in vivo Targeted DamID, revealing binding sites related to neurodevelopment and autism-relevant biology.

Bcl6 promotes neurogenic conversion through transcriptional repression of multiple self-renewal-promoting extrinsic pathways.

The paper shows Bcl6 promotes neurogenic conversion by repressing extrinsic self-renewal pathways like Wnt through transcriptional silencing.