Axel Imhof

The paper establishes hybrid Drosophila cell lines to study genome instabilities and identifies incompatibility genes and chromosomal regions prone to loss in hybrids.

This study identifies reversible and persistent molecular changes in diet-induced obesity using multi-omic analysis, showing that microbial functional profiles drive persistent alterations.

The paper uses mass spectrometry to analyze histone modifications during mitotic entry, identifying three phosphorylation programs and showing H3 T3 phosphorylation marks heterochromatin, not just centromeres.

This study uses mass spectrometry imaging and laser capture microdissection to analyze histone proteoforms in RTT mouse models, revealing neuron-specific differences and mutation-dependent chromatin changes.

The paper identifies DDK-mediated phosphorylation of INO80's Arp8 subunit, which stabilizes the complex and regulates nucleosome spacing at replication origins, enhancing replication efficiency and stress response.

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

The paper determines the intrinsic substrate selectivity of the Drosophila Tip60 acetyltransferase complex using synthetic nucleosome arrays and identifies variable acetylation site effectiveness of an inhibitor.

The paper identifies hangover's role in regulating gene expression by inhibiting NSL-mediated H4K16 acetylation at transcriptional start sites in Drosophila.

This study identifies the Tip60 acetylome as a marker of the proliferative state in Drosophila, revealing its role in cell cycle regulation through histone and non-histone acetylation.

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

The paper identifies a molecular switch at the yeast mitoribosomal tunnel exit that regulates cytochrome b synthesis by mediating interactions between translational activators and assembly factors.

This study identifies H3K27ac as an epigenetic barrier to reprogramming-induced cell fate changes using an AI-based approach and shows that reducing H3K27ac improves reprogramming efficiency.

This study shows that H3K4 methylation acts as an epigenetic memory to support zygotic genome activation and embryonic development in Xenopus laevis.

This study shows that Chameau (HBO1) enhances starvation resilience in Drosophila melanogaster at lower temperatures, but its role diminishes at higher temperatures.

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

The paper investigates how cellular and epigenetic contexts influence Neurog2 binding and its functional consequences in mouse embryonic stem cells and neural progenitor cells, revealing cell-type-specific chromatin accessibility and interactors.

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

This paper identifies HMGN5 as a chromatin and RNA binding protein that switches between substrates to regulate gene expression by interacting with nucleosomes and RNA.

The paper shows that inhibiting cell proliferation during Xenopus embryogenesis leads to abnormal histone modification profiles, suggesting that cell division influences chromatin maturation and developmental decisions.

The paper models H4K20 methylation kinetics during Xenopus embryogenesis, showing demethylation is essential in non-cycling cells but dispensable in rapidly dividing cells.

This study identifies Morc3 as a key regulator of ERV silencing by enabling Daxx-mediated H3.3 incorporation, revealing a mechanism for chromatin modification and repression.

The paper models the propagation and stability of K27 and K36 methylation landscapes using computational methods and mass spectrometry data.

The paper presents STATegra, a multi-omics dataset of mouse B-cell differentiation combining 10 omics technologies to study dynamic cellular processes.

The paper introduces a method to improve spectral library coverage in DIA proteomics by using multiple characteristic intensity patterns, achieving near-complete coverage without increasing false discovery rates.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.

The paper uses microscopy and biotinylation to map HMR and HP1a bound chromatin, revealing an intricate structure of the chromocenter and a role for HMR in separating heterochromatin from centromeric chromatin.

The paper investigates the chromatin localization differences of hybrid lethality proteins in Drosophila species and identifies altered protein interactions between gfzf and HMR in hybrids.