The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling
Dorothy Yanling Zhao, Chenchen Mi, Jonathan Wagner, W. Jiang, Itika Saha, Matthias Poege, Peng Xu, Jürgen M. Plitzko, Qiang Guo, Florian Beck, Wolfgang P. Baumeister
This study investigates how VCP and proteasomes degrade non-fibrillar polyQ intermediates in neurodegenerative diseases, revealing a distinct VCP-20S coupling mechanism.
bioRxiv · Apr 1, 2025 · PreprintBiochemistry