Wolfgang P. Baumeister

The paper uses cryo-electron tomography and computational methods to infer the assembly states of actin networks in podosomes, revealing layered helical order and preferred orientation transitions.

The paper uses cryo-electron tomography to study plasmodesmata structure in Physcomitrium patens, revealing callose's role in shaping channels and identifying MCTP protein assemblies.

This study identifies NuMA's role in stabilizing linker histone H1 on chromatin to promote heterochromatin compaction and maintain epigenetic repression.

This study investigates how VCP and proteasomes degrade non-fibrillar polyQ intermediates in neurodegenerative diseases, revealing a distinct VCP-20S coupling mechanism.

This paper describes optimized cryo-ET sample preparation workflows for plant tissues, achieving subnanometer resolution through targeted FIB milling and lamella trimming.

This study identifies UBE3C and NRF1-dependent proteasomal pathways that regulate acute protein aggregate turnover in response to misfolded protein accumulation.

The paper uses cryo-electron tomography to study synaptic vesicle tethering and priming, revealing the role of Munc13 and SNAP25 in confining vesicles and guiding fusion.

This paper introduces DeepFinder, a deep learning method that improves macromolecule identification in 3D cellular cryo-ET data by localizing multiple species with high accuracy.

This study identifies TDP-25 inclusions as sequestering proteasomes, leading to proteostasis impairment in ALS/FTD.

The paper uses cryo-electron tomography to visualize trans-synaptic assemblies linking synaptic vesicles and receptors, showing their precise organization and structure.

The paper develops a method to estimate membrane curvature from cryo-ET data, showing its validity on benchmark surfaces and application to biological data.