Author

Itika Saha

Max Planck Institute of BiochemistryORCID 0000-0002-0289-4082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Anja DeiseriD· 1 shared Barbara HummeliD· 1 shared Carina Fernandez GonzaleziD· 1 shared Chenchen MiiD· 1 shared Dorothy Yanling Zhao· 1 shared F. Ulrich HartliD· 1 shared Florian BeckiD· 1 shared Hauke HolthuseniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Anja DeiserORCID

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2 papers

Recent·Most cited

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Hauke Holthusen, Victoria A. Trinkaus, Carina Fernandez Gonzalez, Itika Saha, Isabelle Pachmayr, Orsolya Kimbu Wade, Anja Deiser, Barbara Hummel, Patricia Yuste‐Checa, Kenneth Ehses, Roman Körner, Rubén Fernández‐Busnadiego, Ritwick Sawarkar, Ralf Jungmann, Mark S. Hipp, F. Ulrich Hartl

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

bioRxiv · Sep 5, 2025 · PreprintCell Biology

The targeting of non-fibrillar polyQ via distinct VCP-proteasome coupling

Dorothy Yanling Zhao, Chenchen Mi, Jonathan Wagner, W. Jiang, Itika Saha, Matthias Poege, Peng Xu, Jürgen M. Plitzko, Qiang Guo, Florian Beck, Wolfgang P. Baumeister

This study investigates how VCP and proteasomes degrade non-fibrillar polyQ intermediates in neurodegenerative diseases, revealing a distinct VCP-20S coupling mechanism.

bioRxiv · Apr 1, 2025 · PreprintBiochemistry