Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation
Morgan L. Jones, Fabienne Beuron, Aaron J. Borg, Andrea Nans, Christopher P. Earl, David C. Briggs, Ambrosius P. Snijders, Maureen Bowles, Edward P. Morris, Mark David Linch, Neil Q. McDonald
The paper reports cryo-EM structures of XPF-ERCC1 in DNA-free and DNA-bound states, revealing an auto-inhibited conformation and activation mechanism.
Nature Communications · Feb 28, 2020Peer-reviewedMolecular Biology