David C. Briggs

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

The paper uses AlphaFold2 and experimental methods to determine new domains in SARS-CoV-2 nsp3, revealing a previously unknown folded domain and suggesting a function for a conserved domain in viral pore assembly.

The paper reports the structure of aPKC-Par6 bound to Lgl1 and proposes a model for its mutual inhibition and release mechanism in cell polarity.

This paper discusses the impact of AlphaFold2 on structural biology, highlighting its accuracy and applications while noting its limitations in predicting conformational variability and posttranslational modifications.

This paper introduces GalNAzMe, a monosaccharide probe that selectively labels O-GalNAc glycosylation in living cells, enabling detailed study of this cancer-relevant modification.

The paper reports cryo-EM structures of XPF-ERCC1 in DNA-free and DNA-bound states, revealing an auto-inhibited conformation and activation mechanism.