Andrea Nans

Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

The paper uses cryo-ET and fluorescence microscopy to study ER exit sites in human cells, revealing COPII and COPI vesicle structures and resolving their origin and organisation.

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.

Mechanisms for cross-neutralisation of diverse bat sarbecoviruses

This study identifies cross-neutralizing mAbs against diverse bat sarbecoviruses and characterizes their conserved epitopes for vaccine design.

In situ cryo-electron tomography of vaccinia virus exit from infected cells

This study uses cryo-electron tomography and SIM to analyze vaccinia virus egress, revealing septin and clathrin roles in viral spread and release.

Molecular model of a bacterial flagellar motor in situ reveals a "parts-list" of protein adaptations to increase torque

The paper determines the in situ structure of a high-torque bacterial flagellar motor using cryogenic electron microscopy, revealing protein adaptations and universal principles of torque generation.

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation

The paper reports cryo-EM structures of XPF-ERCC1 in DNA-free and DNA-bound states, revealing an auto-inhibited conformation and activation mechanism.