Author

Christopher P. Earl

The Francis Crick InstituteORCID 0000-0002-9091-9955Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

David C. BriggsiD· 2 shared Neil Q. McDonaldiD· 2 shared Aaron J. BorgiD· 1 shared Ambrosius P. SnijdersiD· 1 shared André Barros-CarvalhoiD· 1 shared Andrea NansiD· 1 shared Edward P. MorrisiD· 1 shared Eurico Morais‐de‐SáiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

David C. BriggsORCID

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2 papers

Recent·Most cited

BiochemistryNature Structural & Molecular BiologyPeer-reviewedJan 6, 2025

Capture, mutual inhibition and release mechanism for aPKC-Par6 and its multi-site polarity substrate Lgl

Christopher P. Earl, Mathias Cobbaut, André Barros-Carvalho…·Neil Q. McDonald

The paper reports the structure of aPKC-Par6 bound to Lgl1 and proposes a model for its mutual inhibition and release mechanism in cell polarity.

12 citations

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedFeb 28, 2020

Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation

Morgan L. Jones, Fabienne Beuron, Aaron J. Borg…·Neil Q. McDonald

The paper reports cryo-EM structures of XPF-ERCC1 in DNA-free and DNA-bound states, revealing an auto-inhibited conformation and activation mechanism.

50 citations

humanprotein structure

𝕏 PostBluesky