Tau-induced ribosomal collisions impair memory through the activation of the integrated stress response
Harrison Tudor Evans, Srinidhi Venkatesan Kalavai, Victor Wu, Ambika Polavarapu, Emma Balamoti, W. Liu, Olivia Mosto, Drew I. Adler, Vasvi Jain, Eléa Denil, Astra Yu, Esther Assenso, Mauricio Oliveria, Taylor Moniz, Ela N. Golhan, , Eric Klann
This study shows that tau mutations slow ribosomal elongation, causing collisions that activate the integrated stress response, impairing memory and contributing to neurodegeneration.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience