Olivia Mosto

Tau-induced ribosomal collisions impair memory through the activation of the integrated stress response

This study shows that tau mutations slow ribosomal elongation, causing collisions that activate the integrated stress response, impairing memory and contributing to neurodegeneration.

Microglia coordinate activity-dependent protein synthesis in neurons through metabolic coupling

The paper shows microglia support neuronal protein synthesis by coordinating metabolic coupling in response to increased demand from motor tasks.

Neuron type-specific mRNA translation programs provide a gateway for memory consolidation.

The paper identifies neuron-type-specific mRNA translation programs during early memory consolidation and shows they are influenced by mRNA sequence features.

Dynamic and selective engrams emerge with memory consolidation

The paper investigates how memory engrams evolve during consolidation, showing they become selective through inhibitory synaptic plasticity and dynamic composition changes.

Developmental origin and local signals cooperate to determine septal astrocyte identity

The paper shows that intrinsic developmental origins and local signals shape septal astrocyte identity through distinct molecular and morphological features in medial and lateral septal nuclei.

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

This study shows that Sonic hedgehog signaling from cortical neurons regulates astrocyte development and synaptic connectivity during cortical circuit formation.