Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance
Soo‐Yeon Hwang, Helgi Nikoli, Belem Yoval‐Sánchez, Sieun Yang, Peter Martin, Caitlin K. Gribbin, Lalit Sehgal, Lapo Alinari, Robert A. Baiocchi, Inah Hwang, Xiangao Huang, Maurizio DiLiberto, Alexander S. Galkin, Hojoong Kwak, Selina Chen‐Kiang, , Jihye Paik
This study identifies BRG1-driven ferroptosis resistance as a mechanism of BTKi resistance in MCL and shows that BRG1 inhibition restores ferroptotic sensitivity and synergizes with BTKi.
bioRxiv · Sep 2, 2025 · PreprintCancer Biology