CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia
Hugo Muñoz-Hernández, Maxwell Shelley, Skye Kelsall, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, Stephen Mark Roe, Laurence H. Pearl, Michal Wieczorek, Mohinder Pal
This study presents the cryo-EM structure of the R2C complex, revealing how CCDC103 interacts with RUVBL1-RUVBL2 to facilitate dynein motor assembly in PCD.
bioRxiv · Sep 11, 2025 · PreprintBiochemistry