Author

Stephen Mark Roe

University of SussexORCID 0000-0002-7371-9855Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:protein structure· 1

Frequent Co-Authors

John SpenceriD· 2 shared Andrew McGowniD· 1 shared Antony W. OliveriD· 1 shared Chrisostomos ProdromouiD· 1 shared Damien CrépiniD· 1 shared Erika J. ManciniiD· 1 shared Giuliano SiligardiiD· 1 shared Haitham HassaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

John SpencerORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 7, 2026

Structure-function studies of HRIKD-{triangleup}KI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase

Mohan B. Rajasekaran, Jessica Booth, Damien Crépin…·John Spencer

The paper reports the structural analysis of a minimal kinase domain of HRI, showing its ligand-binding conformation and non-productive state, supporting drug discovery for blood cancer.

DOI 10.64898/2026.07.06.735516

humanstructural biology

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BiochemistrybioRxivPreprintSep 11, 2025

CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia

Hugo Muñoz-Hernández, Maxwell Shelley, Skye Kelsall…·Mohinder Pal

This study presents the cryo-EM structure of the R2C complex, revealing how CCDC103 interacts with RUVBL1-RUVBL2 to facilitate dynein motor assembly in PCD.

1 citation

humancryo-EM

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Molecular BiologyBiomoleculesPeer-reviewedJun 28, 2023

The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer's Disease.

Stephen Mark Roe, Zsolt Török, Andrew McGown…·Chrisostomos Prodromou

The paper presents the crystal structure of the Hsp90-LA1011 complex and suggests LA1011 may improve Alzheimer's disease prognosis by disrupting FKBP51 binding to Hsp90.

17 citations

protein structureexperimental assay

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