Laurence H. Pearl

Using Cancer Profiles to Identify Synthetic Lethal Therapeutic Targets and Predictive Biomarkers in Cancer Gene Dependency Data

DepMine identifies synthetic lethal relationships and predictive biomarkers in cancer gene dependency data by integrating genetic profiles and dependency data.

CCDC103-mediated assembly of the R2C complex links RUVBL1-RUVBL2 to Primary Ciliary Dyskinesia

This study presents the cryo-EM structure of the R2C complex, revealing how CCDC103 interacts with RUVBL1-RUVBL2 to facilitate dynein motor assembly in PCD.

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

The paper identifies RIF1-Long as a BRCA1 binding partner that enhances RAD51-dependent repair during DNA replication stress.

The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ

The paper identifies the CIP2A-TOPBP1 axis as a regulator of mitotic DNA repair pathways, showing it promotes MiDAS and MMEJ through distinct mechanisms.

TopBP1 utilises a bipartite GINS binding mode to support genome replication

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function

This paper shows that CK2 phosphorylation of HPV16 E2 on serine 23 promotes interaction with TopBP1, which is critical for plasmid retention and HPV16 immortalization of keratinocytes.