A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS
Natalie Barretto, Benjamin T. Fullerton, Aidan C. Daly, Obadele Casel, Olena Kuksenko, Kristy Kang, Joana Petrescu, Maya Xia, Jacqueline Eschbach, Matthew Leung, Shruti Khiste, Brhan Gebremedhin, Colin Smith, Christopher A. Jackson, Hemali P. Phatnani
This study uses multi-omics data to compare molecular signatures in the motor cortex and lumbar spinal cord of ALS patients, finding distinct alterations in MN and glial functions depending on symptom onset site.
bioRxiv · Jul 28, 2026 · PreprintGenomics