Author

Obadele Casel

New York Genome CenterORCID 0009-0004-0638-0451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:spatial transcriptomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Aidan C. DalyiD· 3 shared Colin SmithiD· 3 shared Hemali P. PhatnaniiD· 3 shared Joana PetrescuiD· 3 shared Kristy KangiD· 3 shared Benjamin T. FullertoniD· 2 shared Brhan Gebremedhin· 2 shared Christopher A. JacksoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Aidan C. DalyORCID

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3 papers

Recent·Most cited

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis

Joana Petrescu, Cláudio Gouveia Roque, Christopher A. Jackson, Aidan C. Daly, Zoé Butti, Kristy Kang, Obadele Casel, Matthew Leung, Luke Reilly, Jacqueline Eschbach, Brhan Gebremedhin, Karina McDade, Jenna M. Gregory, Richard Bonneau, Colin Smith, Hemali P. Phatnani

The paper maps cognitive impairments in ALS by integrating spatial and single-nucleus transcriptomics, revealing distinct cellular and molecular patterns in language and executive dysfunction.

Cell · Aug 4, 2026Peer-reviewedGenomics

A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS

Natalie Barretto, Benjamin T. Fullerton, Aidan C. Daly, Obadele Casel, Olena Kuksenko, Kristy Kang, Joana Petrescu, Maya Xia, Jacqueline Eschbach, Matthew Leung, Shruti Khiste, Brhan Gebremedhin, Colin Smith, Christopher A. Jackson, Hemali P. Phatnani

This study uses multi-omics data to compare molecular signatures in the motor cortex and lumbar spinal cord of ALS patients, finding distinct alterations in MN and glial functions depending on symptom onset site.

bioRxiv · Jul 28, 2026 · PreprintGenomics

Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex

Nick Sloan, Jason A. Mares, Aidan C. Daly, Lilian A. Coie, Shaunice Grier, Natalie Barretto, Obadele Casel, Kristy Kang, Chris Jackson, Maria Pedersen, Shruti Khiste, Benjamin T. Fullerton, Joana Petrescu, Courteney Mattison, Colin Smith, , Hemali P. Phatnani

The paper identifies senescent cell signatures in the human dorsolateral prefrontal cortex using spatial transcriptomics and single nucleus RNA sequencing, revealing heterogeneity and cell-type-specific aging patterns.

bioRxiv · Feb 19, 2025 · PreprintCell Biology