Joana Petrescu

The paper maps cognitive impairments in ALS by integrating spatial and single-nucleus transcriptomics, revealing distinct cellular and molecular patterns in language and executive dysfunction.

This study uses multi-omics data to compare molecular signatures in the motor cortex and lumbar spinal cord of ALS patients, finding distinct alterations in MN and glial functions depending on symptom onset site.

The paper identifies senescent cell signatures in the human dorsolateral prefrontal cortex using spatial transcriptomics and single nucleus RNA sequencing, revealing heterogeneity and cell-type-specific aging patterns.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

PySeq2500 converts the HiSeq 2500 into an open platform for programmable fluidics and imaging, enabling automated multi-day workflows for multiplexed imaging of biological samples.