Kristy Kang

The paper maps cognitive impairments in ALS by integrating spatial and single-nucleus transcriptomics, revealing distinct cellular and molecular patterns in language and executive dysfunction.

This study uses multi-omics data to compare molecular signatures in the motor cortex and lumbar spinal cord of ALS patients, finding distinct alterations in MN and glial functions depending on symptom onset site.

The paper identifies senescent cell signatures in the human dorsolateral prefrontal cortex using spatial transcriptomics and single nucleus RNA sequencing, revealing heterogeneity and cell-type-specific aging patterns.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

The paper extends the RiboTag system for cell-type specific RNA depletion in vitro, showing variable efficiency across replicates.

Splotch aligns spatial transcriptomics data across tissue sections and timepoints to improve gene expression estimates and study optimal experimental design.

Analysis of the ALS spinal cord using Spatial Transcriptomics reveals spatiotemporal dynamics of disease driven gene regulation.