The Escherichia coli replication initiator DnaA is titrated on the chromosome
Lorenzo Olivi, Stephan Köstlbacher, Christina Ludwig, Mees Langendoen, Nico J. Claassens, Thijs J. G. Ettema, John van der OOST, Pieter Rein ten Wolde, Johannes Hohlbein, Raymond H.J. Staals
This study investigates DnaA titration on the E. coli chromosome and shows it controls free DnaA levels in a growth rate-dependent manner, preventing re-initiation during slow growth.
Nature Communications · Aug 21, 2025Peer-reviewedMolecular Biology