Pieter Rein ten Wolde

This study uses a mathematical model to show that circadian clocks in Synechococcus elongatus enhance growth by enabling proteome adjustments that avoid inefficient nighttime growth.

This study investigates how titration of an active DnaA variant controls DNA replication in E. coli under different growth conditions, revealing limits and design principles for synthetic replication systems.

This study investigates DnaA titration on the E. coli chromosome and shows it controls free DnaA levels in a growth rate-dependent manner, preventing re-initiation during slow growth.

The paper develops a convolutional neural network to quantify nuclear localisation of fluorescently tagged proteins in yeast, outperforming existing methods in single-cell time series analysis.

The paper extends a framework for quantifying growth and proteome composition to circadian metabolism in cyanobacteria, showing that storing carbon and nitrogen leads to an optimal growth strategy constrained by slow proteome relaxation.