Methadone Triggers Fetal Membrane Sterile Inflammation Through Innate Immune and Opioid Receptor Signaling
Megan E Kelleher, Hanah M. Georges, Lisa V Salmeron, Ryan Wellington Logan, Kimberly Ann Yonkers, Vikki M. Abrahams
This study shows methadone induces sterile inflammation in fetal membranes via TLR7, TLR8, NLRP3, opioid receptors, and NFκB/MAPK signaling in both human and mouse models.
bioRxiv · Oct 1, 2026 · PreprintImmunology