Vikki M. Abrahams

This study shows methadone induces sterile inflammation in fetal membranes via TLR7, TLR8, NLRP3, opioid receptors, and NFκB/MAPK signaling in both human and mouse models.

This study shows Let-7b-5p promotes trophoblast migration and reduces sFlt-1 through TLR7 and TLR8, and its disruption mimics preeclampsia-like effects.

The paper shows that miR-146a-3p in small extracellular vesicles from viral-stimulated fetal membranes activates TLR7/8 to drive inflammation.

This study shows buprenorphine induces sterile inflammation in human fetal membranes, increasing preterm birth risk via TLR4, NLRP3, and MAPK pathways.

The paper uses quantitative proteomics to compare EV cargo between M1 and M2 macrophages, identifying 132 differentially expressed proteins and their functional roles in immune responses.