Ryan Wellington Logan

This study shows methadone induces sterile inflammation in fetal membranes via TLR7, TLR8, NLRP3, opioid receptors, and NFκB/MAPK signaling in both human and mouse models.

This study shows that chronic fentanyl-xylazine co-exposure causes sex-dependent changes in sleep, respiratory function, and molecular markers in mice.

This study shows disrupting astrocyte molecular rhythms in the nucleus accumbens increases binge-like drinking in mice without affecting other behaviors.

The paper identifies genomic loci associated with cellular rhythms in Diversity Outbred mice using QTL mapping and connects them to circadian regulation and complex traits.

This study maps morphine-induced brain activity in male and female mice over time, revealing sex-specific and time-dependent patterns of c-Fos expression.

This study identifies sex-specific transcriptional changes in the SCN of rats during oxycodone withdrawal and abstinence, linking these changes to addiction-related behaviors.

SleepInvestigatoR streamlines sleep analysis in rodents by automating calculations and visualization of sleep metrics from scored files.

The paper shows aging reduces mRNA expression of dopamine and glutamate markers in midbrain neurons of mice and humans, but not protein levels or cell numbers.

This study shows buprenorphine induces sterile inflammation in human fetal membranes, increasing preterm birth risk via TLR4, NLRP3, and MAPK pathways.

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

This study examines how neonatal fentanyl exposure in mice affects sleep and circadian rhythms during adolescence, finding altered sleep-wake patterns.

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

This study examines how 2-AG affects sleep and circadian rhythms in male and female mice during fentanyl withdrawal, finding sex-specific effects on sleep disruption.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

This study examines how cocaine and morphine affect diurnal proteome rhythms in the mouse nucleus accumbens, revealing distinct pathway alterations.

The paper characterizes striatal projection neuron heterogeneity in mice using single-nuclei multi-omics and spatial mapping, revealing distinct subtypes with unique receptor expression and disease risk contributions.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

This study investigates the sex-specific role of NPAS2 in fentanyl-induced analgesia, tolerance, hyperalgesia, and dependence using NPAS2-deficient mice.

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

This study shows that manipulating SCN neural activity in mice affects anxiety-like behavior but not depressive-like behavior, with dampened activity rhythms correlating with increased anxiety.

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.

The paper identifies VGLUT expression as a sex-dependent mediator of age-related dopamine neuron vulnerability in Parkinson's disease.

This study investigates how NPAS2 mutations affect cocaine self-administration in mice, showing sex- and time-of-day-dependent changes in reward and motivation.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.