Systematic multi-trait AAV capsid engineering for efficient gene delivery
Fatma-Elzahraa Eid, Albert Tian Chen, Ken Y. Chan, Qin Huang, Qingxia Zheng, Isabelle G. Tobey, Simon Pacouret, Pamela P. Brauer, Casey Keyes, Megan M. Powell, Jencilin Johnston, Binhui Zhao, Kasper Lage, Alice F. Tarantal, Yujia A. Chan, Benjamin E. Deverman
The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.
bioRxiv · Dec 22, 2022 · PreprintSynthetic Biology