Author

Casey Keyes

Broad InstituteORCID 0000-0001-8763-0221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Albert Tian CheniD· 2 shared Benjamin E. DevermaniD· 2 shared Fatma-Elzahraa EidiD· 2 shared Isabelle G. TobeyiD· 2 shared Jencilin Johnston· 2 shared Ken Y. ChaniD· 2 shared Pamela P. Brauer· 2 shared Qingxia ZhengiD· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Albert Tian ChenORCID

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Author profile →

2 papers

Recent·Most cited

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

Qin Huang, Ken Y. Chan, Jason Hongliu Wu, Nuria Roxana Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, C.-L. Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, , Benjamin E. Deverman

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

Science · May 16, 2024Peer-reviewedNeuroscience

Systematic multi-trait AAV capsid engineering for efficient gene delivery

Fatma-Elzahraa Eid, Albert Tian Chen, Ken Y. Chan, Qin Huang, Qingxia Zheng, Isabelle G. Tobey, Simon Pacouret, Pamela P. Brauer, Casey Keyes, Megan M. Powell, Jencilin Johnston, Binhui Zhao, Kasper Lage, Alice F. Tarantal, Yujia A. Chan, Benjamin E. Deverman

The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.

bioRxiv · Dec 22, 2022 · PreprintSynthetic Biology