Author

Simon Pacouret

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benjamin E. DevermaniD· 3 shared Jencilin Johnston· 3 shared Ken Y. ChaniD· 3 shared Pamela P. Brauer· 3 shared Qingxia ZhengiD· 3 shared Albert Tian CheniD· 2 shared Alexander SvanbergssoniD· 2 shared Casey KeyesiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Benjamin E. DevermanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BI-TfR1 CapX rapidly transits the blood-brain barrier for efficient, low-dose gene delivery throughout the CNS

Ken Y. Chan, Chin-Yen Lin, Qin Huang, Simon Pacouret, Qingxia Zheng, John W. Harvey, Pamela P. Brauer, Jencilin Johnston, Fiona E. Serack, Jessie R. Davis, Nikita G Kamath, Saša Jereb, Daniel A. Sprague, Alexander Svanbergsson, Magalie Boucher, , Benjamin E. Deverman

The paper describes BI-TfR1 CapX, a gene delivery vector that efficiently crosses the blood-brain barrier, transduces CNS neurons and astrocytes, and reduces Prnp mRNA with low doses.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

Qin Huang, Ken Y. Chan, Jason Hongliu Wu, Nuria Roxana Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, C.-L. Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, , Benjamin E. Deverman

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

Science · May 16, 2024Peer-reviewedNeuroscience

Systematic multi-trait AAV capsid engineering for efficient gene delivery

Fatma-Elzahraa Eid, Albert Tian Chen, Ken Y. Chan, Qin Huang, Qingxia Zheng, Isabelle G. Tobey, Simon Pacouret, Pamela P. Brauer, Casey Keyes, Megan M. Powell, Jencilin Johnston, Binhui Zhao, Kasper Lage, Alice F. Tarantal, Yujia A. Chan, Benjamin E. Deverman

The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.

bioRxiv · Dec 22, 2022 · PreprintSynthetic Biology