Author
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Ken Y. Chan, Chin-Yen Lin, Qin Huang…·Benjamin E. Deverman
The paper describes BI-TfR1 CapX, a gene delivery vector that efficiently crosses the blood-brain barrier, transduces CNS neurons and astrocytes, and reduces Prnp mRNA with low doses.
Saša Jereb, Lia R. D’Alessandro, Nader Morshed…·Benjamin E. Deverman
The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.
Qin Huang, Ken Y. Chan, Jason Hongliu Wu…·Benjamin E. Deverman
The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.
Fatma-Elzahraa Eid, Albert Tian Chen, Ken Y. Chan…·Benjamin E. Deverman
The paper introduces Fit4Function, a machine learning approach to engineer AAV capsids with multiple traits, achieving high transduction efficiency and cross-species prediction.