The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins
Marinda Stanton, Caroline Elizabeth Scheuing, Mahamaya N. Biswal, Bharti Singal, Megha Agarwal, Gerardo Dasaev Vargas, Linyi Gao, Dain R. Brademan, Ruth Hüttenhain, Casey A. Gifford, Tino Pleiner
This study shows the ER membrane protein complex (EMC) acts as a chaperone to facilitate the assembly of voltage-gated calcium channels during their biogenesis.
Nature Structural & Molecular Biology · Oct 30, 2026Peer-reviewedCell Biology