Matthew Miyamoto

Decoding Chromatin Dynamics in Cardiac Organoids Reveals Genetic Drivers of Human Heart Development and Disease

The paper uses a single-cell multi-omic atlas and deep learning to identify cis-regulatory elements and genetic drivers of heart development and disease.

Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretion

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level

The paper develops a transcriptomic entropy metric to benchmark maturation of PSC-derived cardiomyocytes against endogenous tissue using scRNA-seq data.

Noncanonical Notch signals have opposing roles during cardiac development

This study shows noncanonical Notch signaling has stage-specific roles in cardiac development, inhibiting early heart formation but promoting later growth.

PGC1/PPAR Drive Cardiomyocyte Maturation through Regulation of Yap1 and SF3B2

This study identifies PGC1/PPAR signaling and its regulators Yap1 and SF3B2 as key drivers of cardiomyocyte maturation through single-cell transcriptomic analysis across neonatal to adult hearts.

Embryonic organoids recapitulate early heart organogenesis

This paper demonstrates that mouse embryonic stem cells can generate heart-like structures with in vivo-like morphogenesis, supporting cardiovascular progenitors and early heart field compartments.