Neurons undergo pathogenic metabolic reprograming in models of familial ALS
Sean‐Patrick Riechers, Jelena Mojsilovic‐Petrovic, Mehraveh Garjani, Valentina Medvedeva, Casey Dalton, Gerald A. Dienel, Robert Gordon Kalb
The paper identifies metabolic reprogramming in neurons of familial ALS models, showing impaired glycolytic flux with maintained citric acid cycle activity and normal ATP levels.
bioRxiv · Aug 20, 2021 · PreprintNeuroscience