Casey Dalton

This study identifies RAD23A and USP13 as modifier genes that enhance TDP-43 solubility and reduce neuronal toxicity in ALS models.

This paper identifies CSPG4 as a mediator of arginine-rich DPR uptake and cell-to-cell transmission, suggesting it as a therapeutic target for ALS/FTD.

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.

The paper identifies metabolic reprogramming in neurons of familial ALS models, showing impaired glycolytic flux with maintained citric acid cycle activity and normal ATP levels.