Functional and Highly Crosslinkable HIV-1 Envelope Glycoproteins Enriched in a Pretriggered Conformation
Hanh T. Nguyen, Alessandra Qualizza, Saumya Anang, Meiqing Zhao, Shitao Zou, Rong Zhou, Qian Wang, Shijian Zhang, Ashlesha A. Deshpande, Haitao Ding, Amos B. Smith, John C. Kappes, Joseph Sodroski
The paper describes the engineering of HIV-1 Env variants enriched in a pretriggered conformation, which are more stable and crosslinkable, aiding in structural and immunogenic studies.
bioRxiv · Sep 27, 2021 · PreprintMolecular Biology