Joseph Sodroski

This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.

This study investigates how truncations of the HIV-1 Env cytoplasmic tail affect Env cleavage, incorporation into virions, and antibody neutralization.

The paper investigates how many HIV-1 Env protomers need to be modified to stabilize or destabilize the pretriggered conformation, finding that stabilization requires fewer modified protomers than destabilization.

The paper analyzes glycosylation and disulfide bonding of wild-type SARS-CoV-2 spike glycoprotein, finding that Golgi processing leads to complex N-glycans and partial infectivity in a Cys15Phe mutant.

The paper describes the engineering of HIV-1 Env variants enriched in a pretriggered conformation, which are more stable and crosslinkable, aiding in structural and immunogenic studies.

This study investigates the conformational plasticity of the uncleaved HIV-1 Env trimer and its implications for antibody recognition and Env cleavage.

This study uses cryo-EM to reveal two conformational states of the HIV-1 Env precursor, explaining its plasticity and implications for immune response.