Hanh T. Nguyen

This study investigates how truncations of the HIV-1 Env cytoplasmic tail affect Env cleavage, incorporation into virions, and antibody neutralization.

The paper investigates how many HIV-1 Env protomers need to be modified to stabilize or destabilize the pretriggered conformation, finding that stabilization requires fewer modified protomers than destabilization.

The paper describes the engineering of HIV-1 Env variants enriched in a pretriggered conformation, which are more stable and crosslinkable, aiding in structural and immunogenic studies.

This study investigates the conformational plasticity of the uncleaved HIV-1 Env trimer and its implications for antibody recognition and Env cleavage.