Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant Gram-positive bacterial pathogens
Christophe Corre, Gideon Aina Idowu, Lijiang Song, Melanie E. Whitehead, Lona M. Alkhalaf, Gregory L. Challis
This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.
Journal of the American Chemical Society · Oct 27, 2025Peer-reviewedBiochemistry