Christophe Corre

Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii

This paper investigates the multifaceted antibacterial mechanisms of Bald's eyesalve against S. aureus and A. baumannii, showing its potential as a multi-target antimicrobial.

Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant Gram-positive bacterial pathogens

This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.

Early steps of the biosynthesis of the anticancer antibiotic pleurotin

This study identifies the origin of the quinone ring in pleurotin and characterizes a biosynthetic intermediate using genome sequencing and heterologous expression.

Identification of a terpene synthase arsenal using long-read sequencing and genome assembly of Aspergillus wentii

This study uses long-read sequencing and genome assembly to identify terpene synthases and biosynthetic gene clusters in Aspergillus wentii, revealing potential pathways for bioactive molecule production.

DeepGEEP: Data-Driven Prediction of Bacterial Biofilm Gene Expression Profiles

DeepGEEP predicts bacterial biofilm gene expression profiles using synthetic data and a 2D-CNN model, achieving higher accuracy than traditional machine learning methods.

gcFront: a tool for determining a Pareto front of growth-coupled cell factory designs

gcFront identifies Pareto optimal growth-coupled cell factory designs by optimizing cell growth, product synthesis, and coupling strength using a genetic algorithm.

A Streptomyces venezuelae Cell-Free Toolkit for Synthetic Biology

The paper presents an improved Streptomyces venezuelae cell-free TX-TL system with higher protein yields and reduced batch variation, enabling synthetic biology applications.

Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery

This study uses CRISPR/Cas9 to activate a silent gene cluster in Streptomyces sclerotialus, leading to the discovery of scleric acid and its biosynthetic pathway.