Lijiang Song

Discovery of late intermediates in methylenomycin biosynthesis active against drug-resistant Gram-positive bacterial pathogens

This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion

The paper describes the creation of StayRose, a red-shifted variant of StayGold using genetic code expansion, which retains photostability and can be monomerised.

The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins

This study analyzes the TIRome of Arabidopsis to design artificial TIR proteins and identify functional polymorphisms that influence cell death and metabolite production.

Early steps of the biosynthesis of the anticancer antibiotic pleurotin

This study identifies the origin of the quinone ring in pleurotin and characterizes a biosynthetic intermediate using genome sequencing and heterologous expression.

Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery

This study uses CRISPR/Cas9 to activate a silent gene cluster in Streptomyces sclerotialus, leading to the discovery of scleric acid and its biosynthetic pathway.