A PBD-dimer containing antibody drug conjugate targeting CCRL2 for high-risk MDS/AML
Nour Sabiha Naji, Taha S. Ahmedna, J. David Peske, Xinghan Zeng, Brandy N. Perkins, Zanshé Thompson, Tushar D. Nichakawade, Bum Seok Lee, Evangeline Watson, Theodora Chatzilygeroudi, Li Luo, Bogdan C. Paun, Melanie Klausner, Yuju An, Teodora Supeanu, , Theodoros Karantanos
This paper develops an anti-CCRL2 antibody-drug conjugate (ADC) that shows potent cytotoxicity against high-risk MDS/AML cells without harming healthy hematopoietic cells.
bioRxiv · Aug 17, 2025 · PreprintCancer Biology