Spatial Regulation of CAR Signaling Enables Logic-Gated Activity
Tushar D. Nichakawade, Brian J. Mog, Alexander H. Pearlman, Taha S. Ahmedna, Nikita Marcou, Ricardo Mora-Cartín, Evangeline Watson, Bum Seok Lee, Sarah R. DiNapoli, Nickolas Papadopoulos, Chetan Bettegowda, Marco Dal Molin, Denis Wirtz, Drew M. Pardoll, Suman Paul, , Kenneth W. Kinzler
The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.
bioRxiv · May 24, 2026 · PreprintSynthetic Biology