Gabriel Ghiaur

Modular Assembly of an Infectious Clone of the Akata strain of EBV using Synthetic Genomics Methods in Yeast

The paper demonstrates the assembly of an infectious EBV clone using synthetic genomics in yeast, revealing the essential role of the small capsid protein BFRF3 in virus production.

A PBD-dimer containing antibody drug conjugate targeting CCRL2 for high-risk MDS/AML

This paper develops an anti-CCRL2 antibody-drug conjugate (ADC) that shows potent cytotoxicity against high-risk MDS/AML cells without harming healthy hematopoietic cells.

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

The paper identifies serine auxotrophy in AML as a vulnerability driven by PSAT1 suppression, showing sensitivity to serine/glycine restriction and potential therapeutic targeting.

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.