Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy
Shuya Liu, Yu Zhao, Shun Yan Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney Elisabeth Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, , Tobias Bruno Huber
This study uses single-cell RNA sequencing to identify a mechanosensitive MRTF-SRF pathway in early diabetic nephropathy, validated in human datasets and ex vivo experiments.
Genome Medicine · Jan 10, 2023Peer-reviewedMolecular Biology